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Comparative Medicine Imaging Core

The Comparative Medicine Imaging Core at Penn State College of Medicine works in partnership with the Department of Comparative Medicine to provide access to imaging instruments and animal care.

The core is part of the Biomedical Research Core facilities funded through the Office of the Vice Dean of Research, and the core’s staff manages booking, support and maintenance of all imaging equipment. The Comparative Medicine Imaging Core acknowledges support from NIH (S10OD025161).

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Instrumentation and Services

  • The IVIS-Lumina LT Series III (PerkinElmer Inc.) is equipped with full bioluminescence, radioisotope (Cerenkov) imaging capabilities for 2D imaging and standard fluorescence. It provides highly sensitive bioluminescence and fluorescence imaging with physiological relevant molecular and functional information. For help with imaging using the IVIS, contact Dr. Raj Kothapalli at szk416@psu.edu.
  • The MSOT inVision 512-Echo scanner (Multispectral Optoacoustic Tomography scanner from i-Thera Medical) provides in-vivo, full-body, 3D anatomical, functional and molecular imaging capabilities for pre-clinical rodent models. It integrates both ultrasound imaging (which provides anatomical or structural information) with optoacoustic/photoacoustic imaging (which provides functional and molecular information) within one scanner. Complementing IVIS imaging, MSOT provides depth-resolved optical contrast of deeper tissue structures. Some examples include (i) label-free imaging of tissue vasculature and oxygen saturation from of tumors and other structures such as brain and kidneys of rodents. Additional capabilities of this instrument can be found here. For further information and help with imaging using the MSOT, contact Dr. Raj Kothapalli at szk416@psu.edu.
  • The 7T small bore MRI lab houses an actively shielded Bruker BioSpec 70/20 USR 7T system with the Bruker AVANCE Neo architecture and Paravision 360 V2.0 Software. This state-of-the-art scanner includes two transmit channels and can reach a spatial resolution of 25 microns. To book time and learn about additional capabilities, visit the MRI Core page.

Procedures, Protocols and Forms

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Imaging support is provided by Dr. Kothapalli (szk416@psu.edu) for MSOT and IVIS. Support for the 7T MRI can be obtained by visiting Magnetic Resonance Imaging (MRI).

Any animal care or welfare concerns should be addressed to Dr Jennifer Booth (jbooth@pennstatehealth.psu.edu) in the Department of Comparative Medicine.

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All publications, press releases or other documents that result from the utilization of any Penn State College of Medicine Institutional Research Resources including funding, tools, services or support are required to credit the core facility and associated RRID for each core used. Use of an instruments in the Comparative Medicine Imaging Core must include the following:

“The Comparative Medicine Imaging Core services and instruments used in this project were funded, in part, by the Pennsylvania State University College of Medicine via the Office of the Vice Dean of Research and Graduate Students and the Pennsylvania Department of Health using Tobacco Settlement Funds (CURE). The content is solely the responsibility of the authors and does not necessarily represent the official views of the University or College of Medicine. The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations, or conclusions. The Core also acknowledges support from NIH grant S10OD025161.”

Investigators must list the names of the instruments that were utilized in the Materials and Methods section.

Work with Comparative Medicine Imaging

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All fees for comparative medicine imaging instruments are accessible through iLab.

View the Comparative Medicine Imagine Core in iLab

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