Orthopaedics and Rehabilitation: Center for Orthopaedic Research and Translational Science

The Center for Orthopaedic Research and Translational Science (CORTS) was created in 2005 as the Division of Musculoskeletal Sciences and expanded to a center in 2018 to accommodate the expanded scope of basic science, translational research and regenerative medicine interests within the Department of Orthopaedics and Rehabilitation.

Our multidisciplinary scientific staff consists of research technicians, postdoctoral fellows, graduate and undergraduate students and administrative staff. Orthopaedic residents and medical students are actively involved in both basic science and clinical faculty-sponsored projects.

Specific research interests of the faculty include:

  • Molecular biology of cartilage development and osteoarthritis
  • Transgenic animal models of musculoskeletal disease
  • Bone and cartilage cell biology
  • Biophysical signal transduction as it applies to orthopaedic problems
  • Pathophysiology of age-related and post-menopausal osteoporosis
  • Computational biomechanics
  • Effects of exercise on bone and cartilage
  • Assessment of orthopaedic implant function and failure
  • Matrix metalloproteinase expression in connective tissue
  • Tendon/ligament mechanics and mechanobiology
  • Roles of non-coding RNAs and retrotransposons in skeletal biology

Clinical research projects include investigation into thromboembolic disease, heterotopic ossification, and clinical outcome studies of implants and specific operative procedures.