Effective Jan. 25, 2018, NIH policy mandated that all domestic sites participating in a non-exempt, multi-site research study (where study activities outlined in a single protocol are carried out at multiple institutions) use a single IRB (sIRB).
Effective Jan. 20, 2020, the 2018 Common Rule will require a sIRB for all domestic sites participating in a non-exempt, cooperative research study (two or more institutions coordinate to complete a portion of the research outlined in a specific protocol).
Requesting a Reliance Determination
Investigators requesting a reliance determination should complete a Reliance Request Form. If needed for a grant proposal, please submit the request at least one week before the grant submission deadline.
Once reviewed and the reliance determination made, the IRB office will provide a letter of support that describes the selected sIRB and Penn State’s willingness to rely on this IRB or serve as the reviewing IRB.
Note: Penn State’s IRB offices cannot guarantee their willingness to support the use of the sIRB that has been selected without prior consultation and agreement documented in a letter of support.