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Single IRBs and Reliance Requests

Important Dates

Effective Jan. 25, 2018, NIH policy mandated that all domestic sites participating in a non-exempt, multi-site research study (where study activities outlined in a single protocol are carried out at multiple institutions) use a single IRB (sIRB).

Effective Jan. 20, 2020, the 2018 Common Rule will require a sIRB for all domestic sites participating in a non-exempt, cooperative research study (two or more institutions coordinate to complete a portion of the research outlined in a specific protocol).

Requesting a Reliance Determination

Investigators requesting a reliance determination should complete a Reliance Request Form. If needed for a grant proposal, please submit the request at least one week before the grant submission deadline.

Complete the Reliance Request Form here

Once reviewed and the reliance determination made, the IRB office will provide a letter of support that describes the selected sIRB and Penn State’s willingness to rely on this IRB or serve as the reviewing IRB.

Note: Penn State’s IRB offices cannot guarantee their willingness to support the use of the sIRB that has been selected without prior consultation and agreement documented in a letter of support.

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